I use iTunes exclusively. I used to use winamp years ago, but I really like iTunes. I was messing around with somethng called CoverFlow, which was cool. It was just a jukebox feel to it. You'd scroll through all the album covers for every CD you have. Was pretty neat and I'd set it up if I was playing background music at my house while people were over, but that's about it.
I like iTunes because it's really simple, I like how easy I can create new playlists, and most of my podcasts are in there.